Furthermore, CD137 ligation protected BJ137 cells, but not parental BJAB cells, from the decline in viability induced by the JNK inhibitor SP600125 (Fig. 4D), in accordance with a previous report that SP600125 induced apoptosis in various lymphoma cells, including BJAB cells, which was inhibited by BCL-XL [25]. This evidence concerns the gene MAPK8 and lymphoma.