Over the past 15 years, numerous mutations in SCN5A have been reported to be associated with various rare arrhythmia syndromes, such as congenital Long QT syndrome type 3 (LQTS3), Brugada syndrome (BrS), progressive cardiac conduction defect (PCCD), sick sinus syndrome (SSS) and arterial standstill [10]–[14]. Here, SCN5A is linked to sick sinus syndrome.