TSC1 and tuberous sclerosis: More selective loss of Tsc1 was achieved by in utero electroporation of a Cre recombinase expression cassette under a strong constitutive promoter into one hemisphere of embryonic conditional mice, which led to localized white matter heterotopic nodules and tuber-like lesions [24].Given the severity of neurological and cognitive deficits in TSC, efforts continue to try to develop mouse models which recapitulate TSC brain lesions as closely as possible in order to understand the pathophysiology and explore treatment paradigms.