Moreover, the abundant expression of Trop-2 on ME-180 renders these tumor cells highly responsive to (E1)-λ1, with growth inhibition detectable at 1 fM and an EC50 (<0.1 pM) 1000-fold lower than AD2-IFN-λ1 (EC50 ∼100 pM). This evidence concerns the gene IFNL1 and neoplasm.