In this study, LTNP were defined as HIV-infected individuals with no CD4+ T cell decay two years prior to inclusion and CD4+ T cell counts within the reference interval for >10 years without cART and viremia >5,000 copies/mL, as even 7 years of HIV-infection with stable CD4+ T cell counts does not seem to distinguish between LTNP and progressors [13]. The gene discussed is CD4; the disease is HIV infectious disease.