FGFR4 and neoplasm: FGFR4 silencing by shRNAs and siRNAs caused a recovery of epithelial markers like E-cadherin, iii) FGFR4 effects were mediated through SRC, ERK and AKT pathways, with a significant effect on cell survival, iv) silencing of FGFR4 almost abolished tumor growth in mice xenografts, and v) small molecule inhibitors and FGFR4 targeting by specific antibodies diminished cell proliferation in vitro.