However, the expression of sterol regulatory element binding protein (SREBP)-1c, uncoupling protein 2 (UCP2), and PPAR-γ, which are involved in hepatic lipogenesis in high-fat-diet-induced or genetically controlled obesity, was induced in CDAA-diet-fed rat livers and suppressed by MIYAIRI 588. This evidence concerns the gene SREBF1 and obesity due to melanocortin 4 receptor deficiency.