The AA genotype of MMP3 rs650108 and the GG genotype of rs522616 were associated with almost a four-fold increased risk of having a distant tumor versus a tumor staged as localized or in situ (OR 4.1, 95% CI 1.09, 15.39 and OR 3.91, 95% CI 1.04 , 14.71 respectively) relative to the major allele genotype. Here, MMP3 is linked to neoplasm.