Uchino K et al. showed that microRNA (miR)-582-5p and -3p, which were strongly decreased in high-grade bladder cancer clinical samples, both of them suppressed the expression of the same set of target genes such as protein geranylgeranyltransferase type I beta subunit (PGGT1B), leucine-rich repeat kinase 2 (LRRK2) and DIX domain containing 1 (DIXDC1) [39]. This evidence concerns the gene LRRK2 and urinary bladder cancer.