RCC1 and bacterial infectious disease: In our unbiased RNAi screen of C. elegans CME regulators, we found that only CHC-1 and AP2 components obviously affected cell corpse engulfment and degradation while LST-4/Snx9/18/33 and DYN-1/dynamin were essential for phagosome maturation; in contrast, RNAi inactivation of several major CME regulators has been shown to inhibit bacterial infection of mammalian cells.