ATP2C1 and Hailey-Hailey disease: The terminal phenotypes due to pmr-1 disruption, such as ventral enclosure defects and head enclosure failures, are at least superficially similar to the neural tube closure failures in mice lacking the PMR-1 homolog SPCA, as well as the cell adhesion defects observed in Hailey-Hailey disease patients [19], [23], [24].