TK1 and cervical squamous intraepithelial neoplasia: Of the variable prognostic factors studied (pathological stages, FIGO stages, TK1 [TK1 total expression, cytoplasmic/nuclear expression], Ki-67 and age), CIN III versus pathological stage II, FIGO stages 0 versus IA – IIA, total TK1 and cytoplasmic/nuclear TK1 type of expression were found to be independent prognostic factors (Table 4).