INS and Glucose intolerance: Similarly the 0–120’ insulin AUC was significantly higher (p < 0.05) (1093 ± 46 vs. 926 ± 52) (Figure 2E) and the corresponding 0–120’ glucose AUC significantly lower (p < 0.05) (29641 ± 1712 vs. 37716 ± 2767) in the CNX-011-67 treated animals (Figure 2F) when compared to the ZDF control animals indicating development of severe glucose intolerance in the control ZDF animals.