After tolerogenic DEC-205+ dendritic cell vaccination to promote proinsulin-reactive Foxp3+ Treg cell activity, cotransfer of total spleen cells from autoimmune protected NOD donors can delay the onset of diabetogenic splenocyte-mediated diabetes in NOD.Rag1−/− recipients (Figure 3(d)) [21]. Here, RAG1 is linked to diabetes mellitus.