It is not certain whether the particular polymorphism in TRBV9 (Q55H) plays a key role in recognition of the gliadin-HLA-DQ8 celiac disease antigen (see above), though a structural and biophysical study of the TK3 TCR, which is encoded by the TRBV9 gene, found that this particular variant affected the electrostatic makeup and structure of pMHC recognition for HLA-B*35:01 and an EBV peptide [61]. This evidence concerns the gene TRBV9 and celiac disease.