SETD2 and idiopathic pulmonary fibrosis: In fact, it was observed in both animal models of bleomycin-induced fibrosis and in lung tissues of IPF patients that HIF 1-α is overexpressed and may exert its role in early stages of fibrogenesis as it was localized in areas of active fibrosis and in normal areas of IPF lung but not within the fibroblastic foci which represent areas of established fibrosis [42].