PTGS2 and neoplasm: The epidermal growth factor (EGF) and Src kinase induced Stat3 activation mediate series proteins including cell-cycle regulators such as FBJ murine osteosarcoma viral oncogene homolog, mitogen-activated protein kinase 5, c-Myc, and inducers of tumor angiogenesis in invasive breast cancer tissue such as vascular endothelial growth factor, cyclooxygenase-2, matrix metalloproteinase (MMP)-2, MMP-10, and MMP-1[26].