To further investigate whether PRAME gene expression is correlated with the clinical characteristics of leukemia, Paydas [4] examined 74 patients, including 68 patients with de novo acute leukemia, 3 with chronic myeloid leukemia-blastic phase, and 3 with myelodysplastic/myeloproliferative syndrome-blastic transformation. The gene discussed is PRAME; the disease is acute leukemia.