AAAS and nervous system disorder: Genetic linkage analysis revealed a locus on chromosome 12q13 that is commonly mutated in individuals with Allgrove syndrome [14] and, subsequently, the gene called AAAS encoding for a protein of 547 amino acids, called ALADIN (alacrima/achalasia/adrenal insufficiency/neurologic disorder), was identified as the site of mutations in Allgrove syndrome [15, 16].