Various agents have previously been reported to cause such pulmonary side effects as fibrosing alveolitis (e.g. bleomycin, busulfan, or trastuzumab) or granulomatous lung disease (e.g. methotrexate, BCG, TNF-α blocking agents, gefitinib, or everolimus) [26–32]. This evidence concerns the gene TNF and idiopathic pulmonary fibrosis.