SDC1 and prostate neoplasm: Benign glands also showed significantly higher intensity staining for syndecan-1 than localised prostate cancer, and no significant association between syndecan-1 expression in prostate tumours and any of the following: Gleason score, pathological stage, surgical margin status, and biochemical recurrence was shown, suggesting that syndecan-1 is not an independent predictor of recurrence or tumour-specific survival and diminishing its significance as a clinical marker [17].