Expression of main heparan sulfate proteoglycans (glypican-1, perlecan, and syndecan-1) and chondroitin/dermatan/keratan sulfate proteoglycans (aggrecan, versican, NG2, brevican, decorin, and lumican) was studied in normal, benign, and cancer human prostate tissues by RT-PCR and immunohistochemical analyses. This evidence concerns the gene VCAN and cancer.