IL1B and coronary artery disorder: Therefore, our results suggest that allele 2 of IL-1α+4845 might be a risk indicator for CHD, and thereby these findings were in agreement with previous studies indicating that patients with genotype 1.2 or 2.2 at the IL-1α+4845 polymorphism had higher median CRP (2.92 versus 2.05 mg/L, Pi = 0.023), and CRP levels remained significantly associated with IL-1 polymorphisms after adjustment for smoking, gender, and age [41].