Kalinowski demonstrated that African Americans have increased levels of oxidative stress resulting in endothelial dysfunction when compared to Caucasians [32], and we also previously demonstrated that compared to Caucasian endothelial cells, African American endothelial cells had significantly greater protein expression levels of NADPH oxidase, the principal source of reactive oxygen species in endothelial cells [33]. The gene discussed is FMO5; the disease is endothelial dysfunction.