NFE2L2 and Hepatic fibrosis: Wang and colleagues administered blueberry juice to rats with CCl4-induced hepatic fibrosis and found an increase in the expression of the transcription factor, NF-E2-related factor 2 (Nrf-2), and its downstream target, the antioxidant enzyme NADPH quinone oxidoreductase (Nqo1), which are central to hepatic stellate cell cytoprotection [55].