Suh et al. and Chiou et al. found that pterostilbene treatment downregulated the inflammatory enzymes nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2), which stimulate production of proinflammatory cytokines and induce proliferation of colon cancer cells [46, 47]. Here, PTGS2 is linked to malignant colon neoplasm.