A pancreatic cancer genomic analysis of pterostilbene revealed downregulation of multiple apoptosis-related genes including MnSOD, DNA-damage-inducible transcript 3 (DDIT-3), and growth differentiation factor 15 (GDF-15), also known as macrophage inhibitory cytokine 1 (MIC-1) [64]. Here, GDF15 is linked to familial pancreatic carcinoma.