The unstimulated, antigen stimulated or antigen-specific levels of 8 of the 12 markers evaluated in the current study (IFN-α2, IL-1Ra, IP-10, sCD40L, IFN-γ, VEGF, TGF-α and EGF), were different between children with TB disease and those without disease, and/or between the QFT-IT positive children with disease and those without, irrespective of HIV infection. Here, IFNG is linked to HIV infectious disease.