CXCL8 and Sepsis: For example, Nakanaga T et al [37] showed Duox1 mediated PA-LPS-induced IL-8 production in airway epithelial cells, and Kong X et al [38] showed NADPH oxidase-deficiency (Gp91phox−/− mice) significantly reduced LPS-induced sepsis in Nrf2−/− mice.