The haplotypes FTO H3: AAAGC and GNB3 Hc: CT and Hd: TT increased the risk of hypertension with ORs of 1.48 (P = 0.005), 1.74 (P = 4.36E–05) and 1.79 (P = 1.79E–04), respectively, while haplotypes FTO H4: CTGAC and GNB3 Ha: TC with ORs of 0.38 (P = 5.45E–05) and 0.49 (P = 2.12E–11), respectively, were protective. The gene discussed is GNB3; the disease is hypertensive disorder.