To address this question, we screened the potential single nucleotide polymorphisms (SNPs) of FTO and GNB3 in a case-control design and looked for their interactive effect in hypertension pathohysiology in correlation with clinical parameters including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and body mass index (BMI). Here, FTO is linked to hypertensive disorder.