To address this question, we screened the potential single nucleotide polymorphisms (SNPs) of FTO and GNB3 in a case-control design and looked for their interactive effect in hypertension pathohysiology in correlation with clinical parameters including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and body mass index (BMI). This evidence concerns the gene GNB3 and hypertensive disorder.