Association of TLR molecules with disease susceptibility in sheep has been suggested, based on their differential expression patterns between infected and non-infected animals and the results of association analysis of specific polymorphic sites with disease status; So far, SNPs in TLR1, TLR2, TLR4, TLR6 and TLR10 have produced suggestive associations with differential susceptibility to Mycobacterium infection [8], [12], [13], [14]. This evidence concerns the gene TLR2 and Mycobacterium infection.