Other studies assessing predictors for IRIS in HIV+ patients with co-morbidities other than TB (predominantly Pneumocystis jirovecii pneumonia with many patients receiving corticosteroids at ART initiation) found associations with another innate immune cytokine, IL-8, and failed to show involvement of IL-6 [37], arguing that IL-6 might play a more critical or specific role in mycobacterial IRIS. This evidence concerns the gene CXCL8 and tuberculosis.