This indicated that while expression of the human CD4, CCR5 and cyclin T1 transgenes enabled the hCD4/R5/cT1 mouse CD4+ T cells and myeloid-lineage cells to be infected with HIV-1, hCD4/R5/cT1 mouse myeloid-lineage cells supported infection more robustly than the CD4+ T cells. The gene discussed is CD4; the disease is infection.