Another study reported that G2258A TLR2 allele in transfected HEK293 cells had a decreased IL-8 secretion after stimulation by lipoteichoic acid, heat-inactivated Staphylococcus aureus or triacylated lipopeptides, and it was associated with suppressed IL-8 production by monocytes in AD patients as well [43]. This evidence concerns the gene TLR2 and Alzheimer disease.