Using a TLR4 scoring system (negative = 0, low positive = 1, positive = 2, high positive = 3), we demonstrate that 22% of adenomas and 38% of sporadic CRCs show increased expression of TLR4 (score 2–3) compared to 8% of normal tissues (8% score 2–3, 92% score 0–1) (Figure 1b). This evidence concerns the gene TLR4 and adenoma.