While overexpression of miR-219-5p resulted in the reduced migration of U87-parental cells (60% decrease; p<0.001), it did not have any effect on migration of U87-wtEGFR and U87-ΔEGFR cell lines (Figure 5C, 5D) which indeed suggested that the inhibitory effect of miR-219-5p on glioma cell migration was because of its ability to target EGFR. This evidence concerns the gene EGFR and central nervous system cancer.