Gene expression of forkhead transcription factor A2 (FOXA2), glycogen synthase kinase-3 alpha (GSK3α), and insulin like growth factor binding protein-1 (IGFBP-1), proteins whose activities are all regulated by insulin, were increased with HF IU compared to C IU liver (Table 3). The gene discussed is IGFBP1; the disease is hydrops fetalis.