One group is characterized by specific and balanced translocations, which include the integration of individual translocation genes (for example, alveolar rhabdomyosarcoma has PAX3-FKHR) and the other group typically shows more extensive chromosomal rearrangements leading to recurrent, but non-specific, chromosomal gains or losses [2]. The gene discussed is FOXO1; the disease is rhabdomyosarcoma.