FERMT2 and cardiomyopathy: In summary, the findings identify Fermitins as important mediators of cardiomyocyte coupling and heart function in Drosophila. Given the evolutionary conservation between invertebrate Fermitins and mammalian Kindlins, the evidence supports the hypothesis that disruption of cardiomyocyte KIND2 may lead to abnormal intercalated discs and cardiomyopathies in humans.