Univariate analysis revealed that male gender (P = 0.024), gastrointestinal bleeding (P = 0.029), tumor size >5 cm (P<0.001), non-gastric site (P<0.001), mitotic index >5/50HPFs (P<0.001), necrosis (P = 0.003), epithelioid or mixed cell type (P = 0.030), surrounding tissue invasion (P = 0.002), AFIP-Miettinen high and moderate risk (P<0.001), Ki67≥5% (P<0.001), p16>20% (P = 0.021), p53 index ≥10 (P = 0.012), SKP2>10% (P<0.001), and KIT exon 11 deletion (P = 0.022) were significantly associated with reduced recurrence free survival (RFS). Here, SKP2 is linked to neoplasm.