In the present study, to detect the promoter activity of CDH1/E-cadherin by measuring the fluorescence intensity of ZsGreen1 protein in our function-based screening, we established a unique cell-based reporter system using a pancreatic cancer cell line, Panc1, having phenotypic plasticity at EMT/mesenchymal-to-epithelial transition (MET). This evidence concerns the gene CDH1 and familial pancreatic carcinoma.