EP300 and thyroid gland carcinoma: Since the mono-methylation at histone 3 lysine 4 (H3K4me1) and transcriptional co-activators (p300 and MED1) can accurately predict enhancer activity at many loci, we performed site-directed ChIP assays for H3K4me1, P300 and MED1 of lymphoblastoid cell lines established from one thyroid carcinoma patient with the 4q32A>C heterozygous genotype and one control with the wild type A/A genotype.