In this regard, there are genetically engineered mice models that target epidermal keratinocytes and are sufficient to initiate psoriasis like phenotype [29, 30] such as the IKK2 knockout mice [29, 30] and the JunB/c-Jun double knockout mouse [23], and both of them resemble many features of psoriasis that are T cell independent. This evidence concerns the gene IKBKB and psoriasis.