Importantly, similar mutations that create active Spi-B-binding sites adjacent to the TATA boxes of archetype-like viruses have been described in the brain of a patient with cerebellar atrophy and in intestinal biopsies of Crohn's disease patients treated with infliximab, suggesting that this type of mutation is supported during dissemination in the host. This evidence concerns the gene SPIB and Cerebellar atrophy.