Many other reports show an hemostatic disequilibrium, mainly in the active form of IBD, documenting higher levels of procoagulant factors (XI, XII, X, V), prothrombin and side-products of prothrombin cleavage and, on the other hand, lower or normal levels of anticoagulant factors (protein S, protein C, and antithrombin III) and a reduced activity of the fibrinolytic system [126–131]. This evidence concerns the gene F2 and inflammatory bowel disease.