Particularly, there is a strong association between hypoadiponectinemia and T2D [3]: both adipose adiponectin mRNA expression and circulating adiponectin levels are significantly reduced in most rodent models of T2D, as well as T2D patients; the degree of glycosylated adiponectin and “high-molecular weight/total adiponectin ratio,” which correlates with insulin sensitivity, were significantly decreased in T2D patients compared to healthy controls; high adiponectin levels are associated with reduced risk of developing diabetes. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.