Ethnicity and family history of osteoporosis are important factors influencing the incidence of osteoporosis; also, Cauley reported rates of fragility fracture differ depending on race/ethnicity and are typically higher among those of White race [28]; Rybakowski et al. improved the functional polymorphism −1149 G/T (rs1341239) of the prolactin gene, and the G allele was associated with a diagnosis of schizophrenia in antipsychotic-induced osteoporosis [29]. This evidence concerns the gene PRL and osteoporosis.