PTX3 and Left ventricular diastolic dysfunction: PTX3 levels were significantly elevated in patients with HF but normal ejection fraction (HFNEF) and the protein was observed in the coronary circulation in patients with left ventricular diastolic dysfunction (LVDD) [97] indicating that PTX3, but not high-sensitivity CRP, is an independent inflammatory marker correlated with the presence of LVDD and HFNEF.