Further studies confirmed that PTX3 represents a more specific marker for acute coronary syndrome (ACS) compared to neutrophil activating peptide-2 (NAP-2) and cardiac troponin I (cTnI) in patients with unstable angina pectoris, NSTEMI, and STEMI within the first six hours of the onset of chest pain [92]; furthermore its coronary sinus plasma levels positively correlate with the Gensini score and negatively with multidetector-row computed tomography plaque density (while hsCRP did not) [93]. This evidence concerns the gene TNNI3 and intermediate coronary syndrome.