When age as well as the potential confounders of sex, BMI (for leptin), waist (for adiponectin), CRP concentrations and angiotensin converting inhibitor, diuretic, and statin use were adjusted for, leptin and adiponectin concentrations remained higher in non-RA compared to RA subjects (P < 0.0001 and 0.0002, resp). The gene discussed is LEP; the disease is rheumatoid arthritis.