CTF1 and cardiac hypertrophy: Although a 10-day treatment with CT-1 did not cause any cardiac hypertrophy nor cardiac enlargement, a prolonged therapy with CT-1 (20 μg/kg per day for 6 weeks) has been shown to increase myocardial dilatation and fibrosis, renal glomerular and tubule-interstitial fibrosis, arterial stiffness, and collagen content independently of blood pressure levels in CT-1-treated Wistar rats as compared to control vehicle.