Finally, it is important to highlight that considering that Aβ pathology depends on the presence of tau [109, 110] and that Aβ deposition is absent in many tauopathies (neurodegenerative diseases associated with the pathological aggregation of tau), it is absolutely necessary to pursue a tau-targeted treatment probably in combination with an Aβ-targeting approach. Here, MAPT is linked to neurodegenerative disease.