The effect of TLR9-dependent systemic inflammation as well as organ dysfunction seems to be dose dependent as a low concentration (0.25 nmol/g) can serve as a mild stimulus for cardiac preconditioning [13], whereas higher concentrations in the range from 0.5 to 1 nmol/g induce sepsis-like inflammation [7, 17]. The gene discussed is TLR9; the disease is Sepsis.