In addition to hemodynamic alterations and HF,50 doxorubicin treatment has been shown to decrease ucps expression.51–52 Thus, although our study focused on the role of ucp3 during conditions of myocardial ischemia, it is also possible that this protein might be involved in the pathogenesis of different pathological cardiac conditions, such as those induced by cardiotoxic chemotherapy drugs. Here, UCP3 is linked to myocardial ischemia.